Using Phylogeny Approach on Ethnobotanical Bioprospecting for Leading Antimalarial Plant-Based Drug Discovery

• DOI: 10.18517/ijaseit.11.2.12973
• Publication Date: 2021-04-27T14:13:41Z
• Authors: Desy Liana; Kanchana Rungsihi...
• Keywords: Bioprospecting; Ethnobotany; Burseraceae

Ethnobotanical-directed bioprospecting has made a significant contribution to modern drug discoveries. However, merely relying on this approach may spend more expenditure, time-consuming, and lead exhaustive laboratory testing due the tremendous data of medicinal plants used occurrence placebo effect during traditional medical treatment. Combining phylogeny with ethnobotanical become new prospective tools plant-based discovery, including antimalaria. This study aimed map ethnomedicinal by various indigenous cultures investigate clustered pattern its antimalarial properties for future bioprospecting. The Internal Transcribed Spacer (ITS) region sequences selected 280 taxa obtained from NCBI (National Center Biotechnology Information) were aligned MUSCLE multiple alignments. They further analyzed using Maximum Likelihood Phylogenetic Test MEGA X software construct phylogenetic tree. Our research revealed that plant malaria treatment was clumped in several families, Apocynaceae, Euphorbiaceae, Rubiaceae, Rutaceae, Fabaceae strongly along fever Asteraceae family. Interestingly, our finding showed these sub-family producing species, Asteroidea. Furthermore, clumping also shown tribe Heliantheae alliance sub-family. supports predictive power select candidate discovery.