Investigation of Thermodynamic and Morphological Properties of Crystalline 4-HPG (4-hydroxyphenylglycine) Using Raman, PXRD and DTA/TGA

• DOI: 10.18596/jotcsa.1369980
• Publication Date: 2024-04-30T18:50:21Z
• Authors: Mustafa Ergin
• Keywords: Powder Diffraction; Characterization

This study focuses on the detailed physical characterization of 4-HPG, a significant impurity found in some most commonly prescribed β-lactam antibiotics worldwide. Various analytical techniques, including X-ray powder diffractometry, dynamic light scattering, scanning electron microscopy, Fourier-transform infrared, and Raman spectroscopy, were employed to characterize properties 4-HPG crystals. XRD analysis revealed crystallinity small crystallite sizes particles, supported by DLS SEM analyses. FT-IR spectroscopy results exhibited excellent agreement, providing insight into structural 4-HPG. Thermal two-stage degradation feature Overall, this contributes better understanding 4-HPG's structure its impact antibiotic stability.