Study on the preparation and drug release property of Modified PEG-DA based hydrogels

• DOI: 10.18596/jotcsa.485817
• Publication Date: 2019-01-11T16:50:38Z
• Authors: Şebnem Şenol; Emel Akyol
• Keywords: Acetophenone

The aim of the present study is to develop hydroxyapatite modified PEG-DA and PEG-DA/HEMA based hydrogels for release Donepezil HCl potential treatment Alzheimer’s disease. [2,2-Dimethoxy-2-phenyl-acetophenone] (Irgacure 651), 1 Hydroxycyclohexyl phenyl ketone 184) 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone 2959) were used as photo-initiators in synthesis was modifying hydrogels. Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) digital utilized investigate characteristics properties Photopolymerization technique selected synthesize Swelling drug studies have been performed under different pH conditions.