SIN-3 as a key determinant of lifespan and its sex dependent differential role on healthspan in Caenorhabditis elegans

• DOI: 10.18632/aging.101682
• Publication Date: 2018-12-13T03:51:46Z
• Authors: Renu Pandey; Meenakshi Sharma; Daman Saluja
• Keywords: Model Organism; Senescence

Aging/senescence includes not just decline in lifespan but also etiologies of age associated morbidities which are inadequately understood. Extensive research has been undertaken to delineate the pathways and generate mutants with extended lifespan. However, little is known about health status these long lived background important genetic perturbations. Caenorhabditis elegans one leading vivo model organisms study aging. Deletion SIN-3, a transcription coregulator C. shown reduce mutant worms by half as compared wild-type isogenic controls. The current focuses on effect SIN-3 deletion healthspan worms. We find that only sin-3 more susceptible stress, overall stress intolerance physiological sex dependent. severity phenotype pronounced hermaphrodites males carrying same mutation respect results further suggest perturbation along gender play an role determining lifespan, fitness organism.