MiR-519d targets HER3 and can be used as a potential serum biomarker for non-small cell lung cancer

• DOI: 10.18632/aging.102908
• Publication Date: 2020-03-14T00:23:32Z
• Authors: Aili Wang; Hongxia Zhang; Jinxiang Wang; Shuming Zhang; Zhenyang Xu
• Keywords: Male; Lung Neoplasms; Receptor, ErbB-3; Middle Aged; Sensitivity and Specificity; 3. Good health; Gene Expression Regulation, Neoplastic; MicroRNAs; 03 medical and health sciences; 0302 clinical medicine; Carcinoma, Non-Small-Cell Lung; Biomarkers, Tumor; Humans; Female; Research Paper; Aged

Development of specific serum biomarkers is essential to improve diagnosis and prognosis non-small cell lung cancer (NSCLC).Here, we show that tissue levels miR-519d are significantly decreased in NSCLC patients.The low expression associated with lymph node metastases, clinical stage, a poor patients.In addition, ROC analysis demonstrated the can distinguish patients from healthy controls.MiR-519d inhibits proliferation, migration, invasion by cells, indicating it may function as tumor suppressor cancer.Furthermore, our data demonstrate HER3 target gene targeting HER3, PI3K/Akt pathway.These findings tissues patients, indicate regulates progression HER3.MiR-519d could potentially serve novel biomarker for NSCLC.