Chronic polypharmacy impairs explorative behavior and reduces synaptic functions in young adult mice

• DOI: 10.18632/aging.103315
• Publication Date: 2020-05-22T20:44:52Z
• Authors: Francesca Eroli; Kristina Johnell; María Latorre Leal; Chiara Adamo; Sarah Hilmer; Jonas W. Wastesson; Angel Cedazo-Minguez; Silvia Maioli
• Keywords: Concomitant

A major challenge in the health care system is lack of knowledge about possible harmful effects multiple drug treatments old age.The present study aims to characterize a mouse model polypharmacy, order investigate whether long-term exposure drugs could lead adverse outcomes.To this purpose we selected five from ten most commonly used by older adults Sweden (metoprolol, paracetamol, aspirin, simvastatin and citalopram).Five-month-old wild type male mice were fed for eight weeks with control or polypharmacy diet.We report first time that young adult polypharmacy-treated showed significant decrease exploration spatial working memory compared group.This impairment was further supported reduction synaptic proteins hippocampus treated mice.These novel results suggest already at age, use affects explorative behavior functions.This underlines importance investigating potentially negative outcomes concomitant administration different drugs, which have been poorly explored until now.The proposed here has translatable findings can be applied as useful tool future studies on polypharmacy.