A two-gene-based prognostic signature for pancreatic cancer

• DOI: 10.18632/aging.103698
• Publication Date: 2020-09-23T16:58:34Z
• Authors: Shuyi Zhou; Yuanliang Yan; Xi Chen; Shuangshuang Zeng; Jie Wei; Xiang Wang; Zhicheng Gong; Zhijie Xu
• Keywords: Nomogram; Univariate; Gene signature; FOXM1

The purpose of this study was to identify a vital gene signature that has prognostic value for pancreatic cancer based on expression datasets from the Cancer Genome Atlas and Gene Expression Omnibus. A total 34 genes were obtained by univariate analysis, which significantly associated with overall survival PC patients. After further Anillin (ANLN) Histone H1c (HIST1H1C) identified considered be most significant among genes. model these two constructed, successfully distinguished into high-risk low-risk groups in training set testing set. Subsequently, independent predictive factors, including age, margin condition risk score, then employed construct nomogram model. area under curve 0.826 at 0.5 years 0.726 1 year, C-index 0.664 higher than others variables alone. These findings have indicated high ANLN HIST1H1C predicted poor outcomes patients cancer. could valuable guidance clinical treatment.