Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma

Male 0301 basic medicine 0303 health sciences Carcinoma, Hepatocellular Liver Neoplasms Aldo-Keto Reductase Family 1 Member C3 Down-Regulation Hep G2 Cells Middle Aged Prognosis 3. Good health 03 medical and health sciences Gene Ontology Area Under Curve Case-Control Studies Cell Line, Tumor Gene Knockdown Techniques Humans Female Protein Interaction Maps RNA, Messenger Oxidoreductases Research Paper Cell Proliferation Proportional Hazards Models
DOI: 10.18632/aging.202380 Publication Date: 2021-01-22T15:24:48Z
ABSTRACT
Hepatocellular carcinoma (HCC) is the most common histological type of primary liver cancer and majority patients are diagnosed at an advanced stage have a poor prognosis. AKR1C3 (Aldo-keto reductase family 1 member C3) AKR1D1 D1) catalyze conversion aldehydes ketones to alcohols play crucial roles in multiple cancers. However, functions HCC remain unclear. In our study, data from public databases were selected as training validation sets, then 76 center chosen test set. Bioinformatics methods suggested was overexpressed down-regulated. The receiver operating characteristic curve (ROC) analysis performed area under (AUC) values above 0.7 (0.948, 0.836, respectively). Also, high expression low predicted prognosis short median survival time. Then, knockdown overexpression cells achieved with lentivirus. And both decreased cell proliferation, restrained viability, inhibited tumorigenesis. Moreover, gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses conducted results showed that might participate MAPK/ERK androgen receptor (AR) signaling pathway. Furthermore, AR phosphorylated ERK1/2 significantly reduced after suppression or AKR1D1. Collectively, serve candidate diagnostic prognostic biomarkers for provide potential targets treatment.
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