The hepatic microenvironment promotes lung adenocarcinoma cell proliferation, metastasis, and epithelial–mesenchymal transition via METTL3-mediated N6-methyladenosine modification of YAP1

• DOI: 10.18632/aging.202397
• Publication Date: 2021-01-26T04:02:53Z
• Authors: Xue-Feng Ni; Quan-Qin Xie; Jie-Min Zhao; Yan-jie Xu; Mei Ji; Wen-Wei Hu; Jun Wu; Chang-Ping Wu
• Keywords: YAP1

The inflammatory microenvironment plays an important role in the onset and progression of lung adenocarcinoma (LUAD), liver is a suitable site metastasis for LUAD cells. However, whether conducive to proliferation, invasion, cells remains unclear. In this study, we confirmed that hepatic stimulated by IL-6 promoted migration, epithelial-mesenchymal transition cells, increased m6A methylation total RNA, transcriptionally activated METTL3 expression. Additionally, YAP1/TEAD signaling pathway increasing modification expression YAP1 mRNA. These results indicate regulating biological functions Further, our study identifies molecular mechanism may provide new strategy early diagnosis, treatment, prognosis patients.