The construction and analysis of a ferroptosis-related gene prognostic signature for pancreatic cancer

• DOI: 10.18632/aging.202801
• Publication Date: 2021-04-04T13:11:25Z
• Authors: Peicheng Jiang; Feng Yang; Caifeng Zou; Tianyuan Bao; Mengmeng Wu; Dongqin Yang; Shurui Bu
• Keywords: Signature (topology); Gene signature

Ferroptosis is a regulated cell death nexus linking metabolism, redox biology and diseases including cancer. The aim of the present study was to identify ferroptosis-related gene prognostic signature for pancreatic cancer (PCa) by systematic analysis transcriptional profiles from Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx). Altogether 14 ferroptosis-relevant genes with potential values were identified, based on which risk score formula constructed. According scores, we classified patients into high- low-risk group. It verified in Gene Omnibus (GEO) ICGC (International Consortium) datasets. Kaplan-Meier survival curves demonstrated that lower scores had significantly favorable overall (OS) (P < 0.0001). area under receiver operating curve (ROC) 12, 18 24 months about 0.8 all patients. result immune status revealed associated infiltration checkpoint blockade (ICB) proteins. In addition, used quantitative real time PCR (q-rtPCR) Human Protein (HPA) validate expression key genes. Collectively, valuable prediction PCa As also has relevance characteristics, it may help improve efficacy personalized immunotherapy.