Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models

• DOI: 10.18632/aging.202868
• Publication Date: 2021-04-20T15:15:52Z
• Authors: Wen-Wen Wang; Ruiyu Han; Hai-Jun He; Jia Li; Si-Yan Chen; Yingying Gu; Chenglong Xie
• Keywords: Male; Neurons; 0303 health sciences; Ubiquitin-Protein Ligases; Mitophagy; Mitochondria; Rats; 3. Good health; Disease Models, Animal; Oxidative Stress; 03 medical and health sciences; Neuroprotective Agents; Cell Line, Tumor; Gene Knockdown Techniques; alpha-Synuclein; Animals; Humans; Quercetin; Parkinson Disease, Secondary; Oxidopamine; Protein Kinases; Research Paper; HeLa Cells

Mounting evidence suggests that mitochondrial dysfunction and impaired mitophagy lead to Parkinson's disease (PD). Quercetin, one of the most abundant polyphenolic flavonoids, displays many health-promoting biological effects in diseases. We explored neuroprotective effect quercetin vivo 6-hydroxydopamine (6-OHDA)-lesioned rat model PD vitro 6-OHDA-treated PC12 cells. In vitro, we found (20 μM) treatment improved quality control, reduced oxidative stress, increased levels markers PINK1 Parkin decreased α-synuclein protein expression Moreover, our findings demonstrated administration also relieved 6-OHDA-induced progressive PD-like motor behaviors, mitigated neuronal death damage accumulation rats. Furthermore, was suppressed by knockdown either Pink1 or Parkin.