Pan-cancer analysis of Methyltransferase-like 16 (METTL16) and validated in colorectal cancer

• DOI: 10.18632/aging.206210
• Publication Date: 2025-02-27T16:25:08Z
• Authors: Ling Liu; Siying Wang; Xuyu Chen; Qian Luo; Zhaoxia Wang; Juan Li

Human Methyltransferase-like 16(METTL16) is an independent N6-methyladenosine (m6A) methyltransferase. Previous studies have proven METTL16 been linked with some types of cancers. However, comparative the relevance across diverse tumors remain sparse. We comprehensively investigated effect expression on tumor prognosis human malignancies by analyzing multiple cancer-related databases like Tumor Immune Estimation Resource (TIMER) and protein atlas (HPA). Bioinformatics data indicated that was overexpressed in most these significantly associated patients cancer, especially colorectal cancer (CRC). Subsequently, <i>In vitro</i> experiments, utility downregulation its could result reduced proliferation migration CRC cells. Our findings reveal novel insights into biological functions types, indicating serve as a prognostic biomarker plays important role cancer.