PDIA6 promotes the proliferation of HeLa cells through activating the Wnt/β-catenin signaling pathway

• DOI: 10.18632/oncotarget.10795
• Publication Date: 2016-07-23T10:28:19Z
• Authors: Huijun Gao; Bing Sun; Hailu Fu; Xinming Chi; Faming Wang; Xiaoyu Qi; Jun Hu; Shujuan Shao
• Keywords: MG132; HeLa; Ectopic expression; Beta-catenin

Protein disulfide isomerase family 6 (PDIA6) belongs to the protein (PDI) family, which function as isomerases and molecular chaperones. PDIA6 has recently been shown promote proliferation growth of various types human cancer cells; however underlying mechanism remains elusive. Here, we report that enhances HeLa cells through activation Wnt/β-catenin signaling pathway. Ectopic overexpression in led increased cell accompanied with accelerated cycle progression. Further mechanistic investigation demonstrated resulted decreased phosphorylation β-catenin at Ser45 Ser33/Ser37/Thr41, while nuclear accumulation, upregulation Wnt/ target genes cyclinD1 c-myc, was abolished by ubiquitin-proteasome inhibitor MG132. These results promoted suppressing β-catenin, thereby inhibiting degradation