Is chronic hepatitis B infection a protective factor for the progression of advanced pancreatic ductal adenocarcinoma? An analysis from a large multicenter cohort study

• DOI: 10.18632/oncotarget.13000
• Publication Date: 2016-11-02T00:08:56Z
• Authors: Qiwen Chen; Zhouyu Ning; Lei Wang; Haifeng Ying; Shu Dong; Chenyue Zhang; Xiaoheng Shen; Yuanbiao Guo; Hao Chen; Xiaoyan Zhu; Yehua Shen; Weidong Shi; Yongqiang Hua; Kun Wang; Junhua Lin; Litao Xu; Lianyu Chen; Lanyun Feng; Xiumei Zhang; Jing Xie; Bo Sun; Yaqin Sun; Wenchao Gu; Mei Kang; Zheng Tang; Zhujun Chen; Zhen Chen; Luming Liu; Jinming Yu; Zhaoshen Li; Zhiqiang Meng
• Keywords: Hepatitis B

// Qiwen Chen 1,2,* , Zhouyu Ning 1,* Lei Wang 3,* Haifeng Ying 4,* Shu Dong Chenyue Zhang Xiaoheng Shen 4 Yuanbiao Guo Hao 1 Xiaoyan Zhu Yehua Weidong Shi Yongqiang Hua Kun Junhua Lin Litao Xu Lianyu Lanyun Feng Xiumei Jing Xie Bo Sun 5 Yaqin 6 Wenchao Gu Mei Kang 2 Zheng Tang Zhujun 7 Zhen Luming Liu Jinming Yu Zhaoshen Li 3 and Zhiqiang Meng Department of Integrative Oncology Oncology, Fudan University, Shanghai Cancer Center, Medical College, Shanghai, China Institute Clinical Epidemiology, Key Laboratory Public Health Safety, Ministry Education, School Health, Digestive Endoscopy Gastroenterology, Changhai Hospital, Second Military Medicine Ruijin Jiao Tong University Medicine, Radiology * These authors have contributed equally to this study Correspondence to: Meng, email: Li, Yu, Keywords : pancreatic adenocarcinoma, HBV Received March 29, 2016 Accepted July 10, Published November 01, Abstract Purpose: Whether the progression advanced ductal adenocarcinoma (PDAC) patients could be affected by exposure remains determined. Therefore, we conducted assess effect infection on PDAC among a large cohort in China. Methods: A multicenter was explore whether liver metastasis overall survival locally metastatic infection. In study, collected 1,526 at three participating hospitals - Hospital from 2004 2013. The association between status then examined. Results: multivariable Logistic regression model, chronic hepatitis B(CHB) inversely associated with synchronous compared non (OR 0.41, 95% CI 0.19-0.85) for stage IV patients. Cox CHB (HR=0.11, 0.02-0.82) is considered as protective factor metachronous Non III For patients, (HR 0.70, 0.51-0.95). Inactive carrier(IC) resolved showed no significant Conclusion: This indicated that may serve an independent which decrease or metastasis, increase