Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma

• DOI: 10.18632/oncotarget.13149
• Publication Date: 2016-11-07T15:27:51Z
• Authors: Nazim Benzerdjeb; Henri Sevestre; Ahmed Ahidouch; Halima Ouadid-Ahi...
• Keywords: Adult; Male; Lung Neoplasms; ORAI1 Protein; Adenocarcinoma of Lung; Adenocarcinoma; Disease-Free Survival; 03 medical and health sciences; 0302 clinical medicine; Biomarkers, Tumor; Odds Ratio; Humans; Neoplasm Invasiveness; Pneumonectomy; Aged; Neoplasm Staging; Aged, 80 and over; Estrogen Receptor alpha; Middle Aged; 3. Good health; Logistic Models; Multivariate Analysis; Female; Research Paper

// Nazim Benzerdjeb 1, 2 , Henri Sevestre Ahmed Ahidouch 2, 3 Halima Ouadid-Ahidouch 1 Laboratory of Cellular and Molecular Physiology, LPCM: EA 4667, SFR CAP-SANTE (FED 4231), UFR Sciences, Amiens, France Department Pathology, Amiens University Hospital, Biology, Ibn Zohr University, Agadir, Morocco Correspondence to: Ouadid-Ahidouch, email: [e-mail] Benzerdjeb, [e-mail] Keywords: orai3, lung adenocarcinoma, prognostic marker, survival Received: June 11, 2016 Accepted: October 17, Published: November 07, ABSTRACT Orai3 channel has emerged as important player in malignant transformation. Indeed, its expression is increased cancer favors cell proliferation by permitting calcium influx. In this study, was overexpressed adenocarcinoma compared to their matched non-tumour samples associated with tumoural aggressiveness. Moreover, estrogen receptor alpha (ERα) visceral pleural invasion multivariate analysis. Furthermore, both the overall (OS) median metastasis free (MFS) tumors high were lower than low regardless stage (35.01 months vs. 51.11 for OS 46.01 62.04 MFS). conclusion, protein level constitutes an independent marker a novel that could help selecting patients worst prognosis be treated adjuvant chemotherapy resectable stage.