Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma
Adult
Male
Lung Neoplasms
ORAI1 Protein
Adenocarcinoma of Lung
Adenocarcinoma
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Biomarkers, Tumor
Odds Ratio
Humans
Neoplasm Invasiveness
Pneumonectomy
Aged
Neoplasm Staging
Aged, 80 and over
Estrogen Receptor alpha
Middle Aged
3. Good health
Logistic Models
Multivariate Analysis
Female
Research Paper
DOI:
10.18632/oncotarget.13149
Publication Date:
2016-11-07T15:27:51Z
AUTHORS (4)
ABSTRACT
// Nazim Benzerdjeb 1, 2 , Henri Sevestre Ahmed Ahidouch 2, 3 Halima Ouadid-Ahidouch 1 Laboratory of Cellular and Molecular Physiology, LPCM: EA 4667, SFR CAP-SANTE (FED 4231), UFR Sciences, Amiens, France Department Pathology, Amiens University Hospital, Biology, Ibn Zohr University, Agadir, Morocco Correspondence to: Ouadid-Ahidouch, email: halima.ahidouch-ouadid@u-picardie.fr Benzerdjeb, nazim.benz@gmail.com Keywords: orai3, lung adenocarcinoma, prognostic marker, survival Received: June 11, 2016 Accepted: October 17, Published: November 07, ABSTRACT Orai3 channel has emerged as important player in malignant transformation. Indeed, its expression is increased cancer favors cell proliferation by permitting calcium influx. In this study, was overexpressed adenocarcinoma compared to their matched non-tumour samples associated with tumoural aggressiveness. Moreover, estrogen receptor alpha (ERα) visceral pleural invasion multivariate analysis. Furthermore, both the overall (OS) median metastasis free (MFS) tumors high were lower than low regardless stage (35.01 months vs. 51.11 for OS 46.01 62.04 MFS). conclusion, protein level constitutes an independent marker a novel that could help selecting patients worst prognosis be treated adjuvant chemotherapy resectable stage.
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