Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma

• DOI: 10.18632/oncotarget.13149
• Publication Date: 2016-11-07T15:27:51Z
• Authors: Nazim Benzerdjeb; Henri Sevestre; Ahmed Ahidouch; Halima Ouadid-Ahi...
• Keywords: Adult; Male; Lung Neoplasms; ORAI1 Protein; Adenocarcinoma of Lung; Adenocarcinoma; Disease-Free Survival; 03 medical and health sciences; 0302 clinical medicine; Biomarkers, Tumor; Odds Ratio; Humans; Neoplasm Invasiveness; Pneumonectomy; Aged; Neoplasm Staging; Aged, 80 and over; Estrogen Receptor alpha; Middle Aged; 3. Good health; Logistic Models; Multivariate Analysis; Female; Research Paper

Orai3 channel has emerged as important player in malignant transformation. Indeed, its expression is increased in cancer and favors cell proliferation and survival by permitting calcium influx. In this study, Orai3 was overexpressed in lung adenocarcinoma as compared to their matched non-tumour samples and was associated with tumoural aggressiveness. Moreover, its expression was associated with estrogen receptor alpha (ERα) expression and visceral pleural invasion in multivariate analysis. Furthermore, both the overall survival (OS) median and the metastasis free survival (MFS) median of tumors with high Orai3 expression were lower than in low Orai3 expression regardless of cancer stage (35.01 months vs. 51.11 months for OS and 46.01 months vs. 62.04 months for MFS). In conclusion, Orai3 protein level constitutes an independent prognostic marker in lung adenocarcinoma, and a novel prognostic marker that could help selecting the patients with worst prognosis to be treated with adjuvant chemotherapy in resectable stage.