Human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis via regulation of B lymphocyte maturation

• DOI: 10.18632/oncotarget.13473
• Publication Date: 2016-11-19T14:07:33Z
• Authors: Tae-Hoon Shin; Byung-Chul Lee; Soon Won Choi; Ji-Hee Shin; Insung Kang; Jin Young Lee; Jae-Jun Kim; Hong-Ki Lee; Jae-Eon Jung; Yong-Woon Choi; Sung-Hoon Lee; Jin-Sang Yoon; Jin-Sub Choi; Chi-Seung Lee; Yoojin Seo; Hyung-Sik Kim; Kyung-Sun Kang
• Keywords: Male; B-Lymphocytes; 0303 health sciences; Cell Differentiation; Mesenchymal Stem Cells; Mesenchymal Stem Cell Transplantation; Coculture Techniques; Dermatitis, Atopic; 3. Good health; Transforming Growth Factor beta1; Disease Models, Animal; Mice; 03 medical and health sciences; Adipose Tissue; Cyclooxygenase 2; Animals; Humans; Mast Cells; Cells, Cultured; Research Paper; Signal Transduction

Mesenchymal stem cell (MSC) has been applied for the therapy of allergic disorders due to its beneficial immunomodulatory abilities. However, underlying mechanisms therapeutic efficacy are reported be diverse according source isolation or route administration. We sought investigate safety and human adipose tissue-derived MSCs (hAT-MSCs) in mouse atopic dermatitis (AD) model determine distribution cells after intravenous Murine AD was established by multiple treatment Dermatophagoides farinae. mice were intravenously infused with hAT-MSCs monitored clinical symptoms. The administration reduced gross histological signatures AD, as well serum IgE level. mostly detected lung heart within 3 days hardly detectable at 2 weeks. All administered survived until sacrifice did not demonstrate any adverse events. Co-culture experiments revealed that significantly inhibited proliferation maturation B lymphocytes via cyclooxygenase (COX)-2 signaling. Moreover, mast (MC) degranulation suppressed hAT-MSC. In conclusion, infusion can alleviate through regulation function.