Suppression of Nestin reveals a critical role for p38-EGFR pathway in neural progenitor cell proliferation

• DOI: 10.18632/oncotarget.13498
• Publication Date: 2016-11-22T21:20:21Z
• Authors: Wentao Hu; Hong Lu; Shang Wang; Wenhan Yin; Xujie Liu; Lin Dong; Richard Chiu; Li Shen; Wen-Jing Lu; Feng Lan
• Keywords: Nestin

The expression of intermediate filament Nestin is necessary for the neural progenitor cells (NPCs) to maintain stemness, but underlying cellular and molecular mechanism remains unclear. In this study, we demonstrated that required self-renew NPCs through activating MAPK EGFR pathways. Knockdown by shRNA inhibited cell cycle progression proliferation in mouse NPCs. Moreover, suppression reduced epidermal growth factor receptor (EGFR) mitogenic effects EGF on these cells. Treatment with p38-MAPK inhibitor PD169316 reversed arrest caused knockdown Nestin. Our findings indicate promotes NPC via pathways, reveals necessity pathways self-renewal.