Association between PPAP2B gene polymorphisms and coronary heart disease susceptibility in Chinese Han males and females

• DOI: 10.18632/oncotarget.14486
• Publication Date: 2017-01-07T00:26:36Z
• Authors: Yu-Xiao Sun; Chuan-Yu Gao; Yang Lu; Xin Fu; Jun-Ge Jia; Yu-Jie Zhao; Lian-Dong Li; Hong-zhi Dui; Xing-Yu Zhang; Zhi-Ying Li; Lei Lei; Wei-Feng Zhang; Yi-Qiang Yuan
• Keywords: Adult; Male; China; 0303 health sciences; Genotype; Phosphatidate Phosphatase; Coronary Disease; Middle Aged; Polymorphism, Single Nucleotide; Linkage Disequilibrium; 3. Good health; 03 medical and health sciences; Logistic Models; Asian People; Gene Frequency; Haplotypes; Risk Factors; Case-Control Studies; Humans; Female; Genetic Predisposition to Disease; Alleles; Research Paper; Aged

// Yu-Xiao Sun 1 , Chuan-Yu Gao 2 Yang Lu 3 Xin Fu 4 Jun-Ge Jia Yu-Jie Zhao Lian-Dong Li Hong-zhi Dui Xing-Yu Zhang Zhi-Ying Lei Wei-Feng Yi-Qiang Yuan Department of Cardiology, The Seventh People’s Hospital, Zhengzhou, Henan, 450016, China Henan Provincial 450000, Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, First Affiliated Hospital Zhengzhou 450052, Correspondence to: Sun, email: [e-mail] Yuan, [e-mail] Keywords: coronary heart disease (CHD), single nucleotide polymorphisms (SNPs), PPAP2B, Chinese Han population, case-control study Received: October 29, 2016     Accepted: December 15, Published: January 04, 2017 ABSTRACT Little is known about gender-related differences in the association between PPAP2B (SNPs) and (CHD) males females. We therefore conducted a with 456 cases 685 healthy controls divided into male female subgroups. Five were selected genotyped using Sequenom Mass-ARRAY technology. Odds ratios (OR) 95% confidence intervals (CIs) calculated unconditional logistic regression adjusting for age gender. Allelic model analysis revealed that rs1759752, allele frequency distributions differed subgroup ( p = 0.015, OR: 1.401, 95%CI: 1.066–1.481). Genetic subgroup, rs1759752 was associated increased CHD risk dominant 0.035) overdominant 0.045). In rs12566304 decreased codominant 0.038) 0.031). Additionally, “GC” haplotypes rs1930760 protective against males. These observations shed new light on gene susceptibility population.