Annexin A13 promotes tumor cell invasion in vitro and is associated with metastasis in human colorectal cancer

• DOI: 10.18632/oncotarget.15523
• Publication Date: 2017-02-22T16:33:37Z
• Authors: Guozhong Jiang; Pengju Wang; Weiwei Wang; Wencai Li; Liping Dai; Kuisheng Chen
• Keywords: Adult; Male; Annexins; Blotting, Western; Kaplan-Meier Estimate; Adenocarcinoma; In Vitro Techniques; 03 medical and health sciences; 0302 clinical medicine; Cell Line, Tumor; Biomarkers, Tumor; Humans; Neoplasm Invasiveness; Aged; Middle Aged; HCT116 Cells; Prognosis; Immunohistochemistry; 3. Good health; Gene Knockdown Techniques; Female; Colorectal Neoplasms; HT29 Cells; Research Paper

Aberrantly upregulated expression of selected members annexin, a group calcium- and membrane-binding proteins, have been found to be associated with metastasis, poor prognosis, other clinical characteristics in colorectal cancer (CRC), the third most diagnosed cancer. However, ANXA13 (encoding protein annexin A13), original founder gene A family, has not studied carefully as potential prognostic biomarker CRC.The level A13 was determined by western blot panel CRC cell lines. Tumor invasion Matrigel vitro assay cells either (via plasmid transfection) or downregulated siRNA treatment) ANXA13. The clinicopathological features values were also evaluated 125 patients.ANXA13 expressed at high HCT116 HT29 but undetected lower SW620, SW48, Rko cells. promoted overexpression SW620 reduced downregulation In patients, levels correlated lymph node metastasis overall survival.ANXA13 is vitro, survival patients. Our results indicate that can exploited for its diagnostic values.