A(H1N1)pdm09 influenza infection: vaccine inefficiency

• DOI: 10.18632/oncotarget.16459
• Publication Date: 2017-03-22T21:46:22Z
• Authors: Nehemya Friedman; Yaron Drori; Rakefet Pando; Aharona Glatman-F...; Hanna Sefty; Ravit Bassal; Yaniv Stein; Tamy Shohat; Ella Mendelson; Musa Hindiyeh; Michal Mandelboim
• Keywords: Pandemic; Strain (injury)

// Nehemya Friedman 1, 2, * , Yaron Drori Rakefet Pando 3 Aharona Glatman-Freedman 3, 4 Hanna Sefty Ravit Bassal Yaniv Stein Tamy Shohat Ella Mendelson 2 Musa Hindiyeh Michal Mandelboim 1 Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Ramat-Gan, Israel Department Epidemiology and Preventive Medicine, School Public Sackler Faculty Tel-Aviv University, Tel-Aviv, The Center for Disease Control, Tel-Hashomer, Departments Pediatrics Family Community Valhalla, New York, USA These authors contributed equally to this work Correspondence to: Mandelboim, email: [e-mail] Keywords: influenza A, H1N1, vaccine, Clade 6B Received: November 22, 2016 Accepted: March 14, 2017 Published: ABSTRACT last pandemic, caused by the swine A(H1N1)pdm09 virus, began in North America at 2009. Since then, World Health Organization (WHO) recommended integration swine-based virus A/California/07/2009 strain yearly vaccinations. Yet, infections with have continued subsequent years. reasons are currently unknown. During 2015–2016 season, we noted an increased prevalence infection Israel. Our phylogenetic analysis indicated that circulating strains belonged 6B.1 6B.2 clades differed from vaccinating strain, approximately 18 amino acid differences found between immunizing strain. Hemmaglutination inhibition (HI) assays demonstrated higher antibodies titer against as compared Israeli strains. We thus suggest current vaccination was not sufficiently effective propose inclusion viruses annual vaccine composition.