Usp5 functions as an oncogene for stimulating tumorigenesis in hepatocellular carcinoma

• DOI: 10.18632/oncotarget.16901
• Publication Date: 2017-04-07T00:50:29Z
• Authors: Yi Liu; Wei-Mao Wang; Ying-Fei Lu; Lu Feng; Li Li; Ming-Zhu Pan; Yu Sun; Chun-Wai Suen; Wei Guo; Jian-Xin Pang; Jin-Fang Zhang; Wei-Ming Fu
• Keywords: 0301 basic medicine; 03 medical and health sciences; Research Paper; 3. Good health

As deubiquitinases, several ubiquitin specific protease members have been reported to mediate tumorigenesis. Although 5 (Usp5) was previously demonstrated suppress p53 transcriptional activity and DNA repair, its role in carcinogenesis remains elusive. In this study, we sought define a novel of Usp5 It found that significantly upregulated hepatocellular carcinoma (HCC) cells most clinical specimens. Further functional investigation also showed knockdown suppressed cell proliferation, migration, drug resistance induced apoptosis; on the other hand, overexpression promoted colony formation, Additionally, inactivated p14ARF-p53 signaling observed overexpressed HCC cells, while activated by knockdown. Therefore, our data contributed hepatocarcinogenesis acting as an oncogene, which provides new insights into pathogenesis explores promising molecular target for diagnosis therapy.