Expression, prognosis and functional role of Thsd7a in esophageal squamous cell carcinoma of Kazakh patients, Xinjiang

• DOI: 10.18632/oncotarget.16966
• Publication Date: 2017-04-08T18:38:51Z
• Authors: Zhichao Hou; Abulajiang Abudur...; Lei Wang; Ayshamgul Hasim; Julaiti Ainiwaer; Haiping Zhang; Madiniyat Niyaz; Halmurat Upur; Ilyar Sheyhidin
• Keywords: Kazakh

// Zhichao Hou 1 , Abulajiang Abudureheman Lei Wang Ayshamgul Hasim 2 Julaiti Ainiwaer Haiping Zhang Madiniyat Niyaz 3 Halmurat Upur 4 and Ilyar Sheyhidin Department of Thoracic Surgery, First Affiliated Hospital Xinjiang Medical University, Urumqi, Uyghur Autonomous Region, PR China Pathology University Xinjiang, Clinical Research Institute, Medicine, Correspondence to: Sheyhidin, email: Keywords : esophageal squamous cell carcinoma, Thsd7a, Kazakh patients, prognosis, function Received December 22, 2016 Accepted March 01, 2017 Published April 08, Abstract Thsd7a (Thrombospondin type domain containing 7a) is a critical transmembrane protein. Studies have indicated that was associated with cytoskeletal organization, migration filopodia formation. However, the involvement remains elusive in human Esophageal Squamous Cell Carcinoma (ESCC). Consequently, immunohistochemistry reverse transcription-polymerase chain reaction were utilized to study correlation between expression clinical-pathological characteristics. The influence on apoptosis, proliferating activity, cycle, migratory invasive capacity determined Eca 109 EC 9706 lines vitro . And activity testified using naked mice model vivo In addition, potential molecular mechanism tested by microarray. It discovered there certain ESCC. By knocking out invasion, proliferation could be decreased. it also arrest cycle at G1 phase increase apoptosis rate. further verified had obvious effect xenograft Eca109 cells. Finally, uncovered microarray analysis variety tumor genes pathways related Thsd7a. Together, demonstrated might degree carcinogenesis