Estrogen promotes tumor metastasis via estrogen receptor beta-mediated regulation of matrix-metalloproteinase-2 in non-small cell lung cancer

• DOI: 10.18632/oncotarget.16992
• Publication Date: 2017-04-10T09:56:45Z
• Authors: Sheng Fan; Yongde Liao; Changyu Liu; Quanfu Huang; Huifang Liang; Bo Ai; Shegnling Fu; Sheng Zhou
• Keywords: Estrogen receptor beta; Fulvestrant; Estrogen receptor alpha

// Sheng Fan 1 , Yongde Liao Changyu Liu Quanfu Huang Huifang Liang 2 Bo Ai Shegnling Fu and Zhou 3 Department of Thoracic Surgery, Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan 430030, Hubei Province, China Hepatic Surgery Center, Pathology, Correspondence to: Liao, email: [e-mail] Keywords: non-small cell lung cancer (NSCLC), estrogen, estrogen receptor beta (ERβ), matrix-metalloproteinase (MMP), metastasis Received: September 14, 2016 Accepted: February 13, 2017 Published: April 10, ABSTRACT In non–small significantly promotes NSCLC growth via (ERβ). However, the effects by which ERβ contributes to in have not been previously reported. This study aims at defining whether stimulation vitro vivo . Here, Our results showed that agonist enhanced aggressiveness two lines (A549 H1793) promoted murine formation. ER-inhibitor Fulvestrant treatment or ERβ-knockdown suppressed migration, invasion nodule formation cells. The expression level protein was analyzed matched samples metastatic lymph node primary tumor tissues from same individuals, we found higher levels were expressed compared tissues. Moreover, Studies on both surgical biopsies cells revealed matrix-metalloproteinase-2 (MMP-2) associated. Furthermore, inhibition resulted down-regulation MMP-2 expression. Taken together, our demonstrate activation through increasing invasiveness-associated MMP-2. These also highlight therapeutic potential ERβin advanced NSCLC.