Tumacrophage: macrophages transformed into tumor stem-like cells by virulent genetic material from tumor cells

• DOI: 10.18632/oncotarget.19320
• Publication Date: 2017-07-18T10:17:40Z
• Authors: Yizhuang Zhang; Na Zhou; Xiuyan Yu; Xuehui Zhang; Shanxin Li; Zhen Lei; Ruobi Hu; Hui Li; Yiqing Mao; Xi Wang; Jinshu Zhang; Yuan Li; Hongyan Guo; David M. Irwin; Gang Niu; Huanran Tan
• Keywords: Tumor progression

// Yizhuang Zhang 1, * , Na Zhou Xiuyan Yu Xuehui 1 Shanxin Li Zhen Lei 5 Ruobi Hu Hui Yiqing Mao Xi Wang Jinshu 2 Yuan 3 Hongyan Guo David M. Irwin 4 Gang Niu and Huanran Tan Department of Pharmacology, Peking University, Beijing, China Clinical Laboratory, The 305 Hospital People’s Liberation Army, Gynaecology Obstetrics, University Third Hospital, Laboratory Medicine Pathobiology, Toronto, Canada N & Genetech Company, Ltd., These authors have contributed equally to this work Correspondence to: Tan, email: [e-mail] Niu, [e-mail] Irwin, [e-mail] Keywords: macrophages, circulating tumor cells, apoptosis, phagocytosis, epithelial tumors Received: May 04, 2017      Accepted: June 20, Published: July 18, 2017 ABSTRACT Tumor-associated macrophages are regarded as tumor-enhancers they key roles in the subversion adaptive immunity inflammatory circuits that promote progression. Here, we show cancer cells can subvert yielding gained pro-tumor functions. When isolated from mice or humans co-cultured with dead cell line induced undergo apoptosis mimic chemotherapy, up-regulation gene expression was identified. Phagocytosis apoptotic by resulted their transformation into stem (initiating)-like indicated markers (e.g., cytokeratin) Oct4) capability differentiate vitro self-renew serum-free media. Moreover, identified a subset monocytes/macrophages blood (breast, ovarian colorectal) patients undergoing chemotherapy harbor transcripts. Our findings uncover new role for development, where be transformed tumor-like potentially horizontal transfer tumor-derived genes, thus, taking advantage these metastasis escaping immune surveillance.