Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress

• DOI: 10.18632/oncotarget.19448
• Publication Date: 2017-07-23T06:47:08Z
• Authors: Wei Zou; Juan Yuan; Zhuo-Jun Tang; Hai-Jun Wei; Wei-Wen Zhu; Ping Zhang; Hong-Feng Gu; Chun-Yan Wang; Xiao-Qing Tang
• Keywords: 0303 health sciences; 03 medical and health sciences; Research Paper; 3. Good health

Diabetes induces impairment in cognitive function. There is substantial evidence that hippocampal endoplasmic reticulum (ER) stress involved diabetic impairment. Hydrogen sulfide (H2S) attenuates the learning and memory decline experimental Alzheimer's disease inhibits ER homocysteine-exposed rats. Therefore, this aim of present work was to investigate whether H2S ameliorates dysfunction involving inhibition stress. In work, we found stretozotocin (STZ, 40 mg/kg)-induced rats exhibited function, as judged by novel objective recognition task (NOR) test, Y-maze test Morris water maze (MWM) test. Notably, treatment with sodium hydrosulfide (NaHS, a donor H2S, 30 or 100 μmol/kg/d, for d) significantly reversed diabetes-induced We also STZ (40 stress, evidenced upregulations glucose regulated protein 78 (GRP78), C/EBP homologous (CHOP), cleaved caspase-12 hippocampus. However, NaHS (30 markedly suppressed increases GRP78, CHOP, expressions hippocampus addition, noted enhanced generation endogenous STZ-induced These results suggest exhibits therapeutic potential diabetes-associated dysfunction, which most likely related its protective effects against