Acrolein induces mtDNA damages, mitochondrial fission and mitophagy in human lung cells

• DOI: 10.18632/oncotarget.19710
• Publication Date: 2017-07-31T10:31:00Z
• Authors: Hsiang-Tsui Wang; Jing-Heng Lin; Chun-Hsiang Yang; Chun-Hao Haung; Ching-Wen Weng; Anya Maan-Yuh Lin; Yu-Li Lo; Wei-Shen Chen; Moon-Shong Tang
• Keywords: Acrolein

Acrolein (Acr), a highly reactive unsaturated aldehyde, can cause various lung diseases including asthma, chronic obstructive pulmonary disease (COPD), and cancer. We have found that Acr damage not only genomic DNA but also repair proteins causing dysfunction enhancing cells' mutational susceptibility. While these effects may account for carcinogenicity, the mechanisms by which induces other than cancer are unclear. In this study, we damages in mitochondrial (mtDNA), inhibits bioenergetics, alters mtDNA copy number human epithelial cells fibroblasts. Furthermore, fission is followed autophagy/ mitophagy Acr-induced trigger apoptosis. However, process does change level of propose loss via mitophagy. These processes mitochondria induced causes lead to diseases.