LncSHRG promotes hepatocellular carcinoma progression by activating HES6

• DOI: 10.18632/oncotarget.19906
• Publication Date: 2017-08-04T03:31:15Z
• Authors: Ying-Chen Xu; Chao-Jie Liang; Dong-Xin Zhang; Guan-Qun Li; Xia Gao; Jian-Zhu Fu; Feng Xia; Jia-Jun Ji; Li-Jun Zhang; Guang-Ming Li; Ji-Xiang Wu
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health; Research Paper

// Ying-Chen Xu 1 , Chao-Jie Liang Dong-Xin Zhang Guan-Qun Li Xia Gao Jian-Zhu Fu Feng Jia-Jun Ji Li-Jun Guang-Ming and Ji-Xiang Wu Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, 100730, China Correspondence to: Wu, email: [e-mail] Li, [e-mail] Keywords: HCC, lncSHRG, SATB1, HES6, proliferation Received: March 21, 2017 Accepted: July 12, Published: August 03, ABSTRACT Hepatocellular carcinoma, one the most common cancers, leads to mass mortality worldwide currently. However, underlying mechanism its oncogenesis remains be elucidated. Here we identified that a long noncoding RNA, lncSHRG was greatly upregulated in human hepatocellular carcinoma samples. We found essential for liver cancer cell tumor propagation mice. In mechanism, recruits SATB1 bind HES6 promoter initiates expression. which is highly expressed promotes proliferation. High expression level positively correlated with clinical severity poor prognosis people carcinoma. Altogether, our research provides new insight on progression.