Long non-coding RNA HOTAIR acts as a competing endogenous RNA to promote malignant melanoma progression by sponging miR-152-3p

• DOI: 10.18632/oncotarget.19910
• Publication Date: 2017-08-04T03:40:21Z
• Authors: Wenkang Luan; Rubo Li; Liang Liu; Xin Ni; Yan Shi; Yun Xia; Jinlong Wang; Feng Lu; Bin Xu
• Keywords: HOTAIR; Competing Endogenous RNA; Tumor progression

// Wenkang Luan 1, * , Rubo Li 2, Liang Liu 3, Xin Ni 4, Yan Shi 3 Yun Xia 1 Jinlong Wang Feng Lu and Bin Xu Department of Plastic Surgery, Affiliated People's Hospital Jiangsu University, Zhenjiang, China 2 Neurosurgery, Nanjing First Hospital, Medical Nanjing, 4 Gastroenterology, These authors have contributed equally to this work Correspondence to: Luan, email: [e-mail] Xu, [e-mail] Keywords: malignant melanoma, ceRNA, HOTAIR, miR-152-3p, c-MET Received: April 15, 2017      Accepted: July 12, Published: August 03, 2017 ABSTRACT HOX transcript antisense RNA (HOTAIR) is associated with the growth metastasis many human tumors, but its biological roles in melanoma remain unclear. In study, we show that HOTAIR overexpressed tissues cells, especially metastatic melanoma. High levels correlate poor prognosis patients. We also determined functions as a competing endogenous (ceRNA) for miR-152-3p. miR-152-3p was decreased acted tumor suppressor functional target Furthermore, promotes cells by competitively binding which functionally liberates mRNA results activation downstream PI3k/Akt/mTOR signaling pathway. acts ceRNA promote progression sponging This finding elucidates new mechanism development provides potential therapeutic