Breast cancer is associated to impaired glucose/insulin homeostasis in premenopausal obese/overweight patients

• DOI: 10.18632/oncotarget.20399
• Publication Date: 2017-08-23T20:31:52Z
• Authors: Raúl M. Luque; Laura M. López-Sá...; Alicia Villa-Osaba; Isabel M. Luque; Ana L. Santos-Romero; Elena M. Yubero-S...; María Cara-García; Marina Álvarez-Be...; José López-Miranda; Manuel D. Gahete; Justo P. Castaño
• Keywords: Carbohydrate Metabolism; Homeostatic model assessment; Homeostasis

// Raúl M. Luque 1, 2, 3, 4, 5, *, # , Laura López-Sánchez * Alicia Villa-Osaba Isabel 3 Ana L. Santos-Romero 6 Elena Yubero-Serrano 7 María Cara-García Marina Álvarez-Benito José López-Miranda Manuel D. Gahete and Justo P. Castaño 1 Maimonides Institute of Biomedical Research Cordoba (IMIBIC), Córdoba, Spain 2 Department Cell Biology, Physiology Immunology, University Hospital Universitario Reina Sofia, 4 CIBERobn, 5 ceiA3, Mammary Gland Unit, Sofía, Lipids Atherosclerosis These authors contributed equally to this work co-directed the should be considered co-senior Correspondence to: Luque, email: [e-mail] Gahete, [e-mail] Castaño, [e-mail] Keywords: breast cancer, glucose, insulin, OGTT, obesity Received: June 27, 2017 Accepted: July 25, Published: August 23, ABSTRACT The association between cancer (BCa) presence altered glucose/insulin metabolism is controversial likely due an inaccurate insulin resistance (IR) assessment inappropriate stratification patients by body-mass index (BMI) menopausal state. 148 women with suspect sporadic BCa were stratified BMI menopause. Fasting levels glycohemoglobin selected IR-related tumor-derived markers measured. Glucose/insulin during OGTT used calculate resistance/sensitivity indexes. Analysis 77 BCa-bearing 71 controls showed IR as demonstrated impaired homeostasis (increased fasting- OGTT-induced glucose levels) deteriorated indexes, which was especially patent in premenopausal women. markedly influenced BMI, being obese significantly more resistant than controls. associated elevated (glucose, triglycerides) (VEGF) markers, overweight/obese patients. but not normal weight or postmenopausal Our data support a bidirectional relationship dysregulated/imbalanced BCa, tumor- IR-markers are correlated impairment