Upregulation of long noncoding RNA Xist promotes proliferation of osteosarcoma by epigenetic silencing of P21

• DOI: 10.18632/oncotarget.20738
• Publication Date: 2017-09-08T19:51:48Z
• Authors: Tianyang Xu; Wenwei Jiang; Lin Fan; Qiuming Gao; Guodong Li
• Keywords: XIST; Small nucleolar RNA

Recent studies show that lncRNAs involve in the initiation and progression of various cancers including osteosarcoma (OS). IncRNA Xist has been verified as an oncogene several human cancers, its abnormal expression was closely associated with tumor progression. Nevertheless, role OS remains unclear. Here, we revealed level up-regulated tissues discovered knockdown significantly repressed cell proliferation. Additionally, mechanistic analysis can repress P21 to regulate cycle proliferation by binding EZH2. Taking all into account, may function promoting potentially serve a novel biomarker therapeutic target for OS.