Augmentation of hypoxia-inducible factor-1-alpha in reinfused blood cells enhances diabetic ischemic wound closure in mice

• DOI: 10.18632/oncotarget.23214
• Publication Date: 2017-12-14T14:27:57Z
• Authors: Huan Wang; Yufeng Feng; Xiaoju Jin; Rong Xia; Yong Cheng; Xiaoqian Liu; Nana Zhu; Xun Zhou; Lei Yin; Jianrong Guo
• Keywords: Hypoxia; Hypoxia-Inducible Factors; HIF1A; Hypoxia-Inducible Factor 1

// Huan Wang 1, * , Yufeng Feng 2, Xiaoju Jin 3 Rong Xia 4 Yong Cheng 1 Xiaoqian Liu Nana Zhu Xun Zhou Lei Yin and Jianrong Guo Department of Anesthesiology, Gongli Hospital, The Second Military Medical University, Shanghai 200135, China 2 First Affiliated Hospital Xiamen 361003, Yijishan to Wannan College, Wuhu 241001, Transfusion Department, Huashan Fudan 200040, Co-first authors Correspondence to: Guo, email: [e-mail] Keywords: diabetic wound closure; blood re-infusion; hypoxia-inducible factor-1a (HIF-1a); vascular endothelial growth factor (VEGF) Received: June 27, 2017 Accepted: August 04, Published: December 13, ABSTRACT Diabetes-associated dysfunction in angiogenesis predominantly contributes impairment closure, but a role alpha (HIF-1a) the process remain poorly understood. Here, we examined whether expression HIF-1a re-infused cells may improve closure mice. We found that isogeneic significantly improved healing mice, seemingly through augmentation wound-associated angiogenesis. Mechanistically, increased macrophage infiltration at site, macrophages produced A (VEGF-A) promote Together, our data suggest reinfused enhance ischemic closure.