Lect2 deficiency is characterised by altered cytokine levels and promotion of intestinal tumourigenesis

• DOI: 10.18632/oncotarget.26335
• Publication Date: 2018-11-23T17:12:32Z
• Authors: Kirsty R. Greenow; Matthew Zverev; Stephanie May; Howard Kendrick; Geraint T. Williams; Toby Phesse; Lee Parry
• Keywords: 0301 basic medicine; 03 medical and health sciences; Research Paper; 3. Good health

Leukocyte cell-derived chemotaxin 2 (Lect2) is a chemokine-like chemotactic factor that has been identified as downstream target of the Wnt signalling pathway. Whilst primary function Lect2 thought to be in modulating inflammatory process, it recently implicated potential inhibitor Deregulation pathway, often due loss negative regulator APC, found ~80% colorectal cancer (CRC). Here we have used ApcMin/+Lect2-/- mouse model characterise role Wnt-driven intestinal tumourigenesis. Histopathological, immunohistochemical, PCR and flow cytometry analysis were employed identify intestine. The mice had reduced mean survival significantly increased number adenomas small intestine with severity. Analysis indicated no effect on pathway but significant differences observed circulating markers, CD4+ T cells, cell lineage-specification factors. In summary, murine promotes initiation progression cancer. This protection performed independently associated an altered environment during tumorigenesis.