Leukemia inhibitory factor receptor is a novel immunomarker in distinction of well-differentiated HCC from dysplastic nodules

• DOI: 10.18632/oncotarget.3136
• Publication Date: 2015-09-15T07:55:06Z
• Authors: Qin Luo; Yurong Zhang; Ning Wang; Guangzhi Jin; Haojie Jin; Dishui Gu; Xuemei Tao; Xisong Huo; Tianxiang Ge; Wenming Cong; Cun Wang; Wenxin Qin
• Keywords: Adult; Male; 0301 basic medicine; Carcinoma, Hepatocellular; Receptors, OSM-LIF; Carcinogenesis; Gene Expression Profiling; Liver Neoplasms; Antigens, CD34; Cell Differentiation; Hep G2 Cells; Middle Aged; 3. Good health; Cohort Studies; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; Cell Transformation, Neoplastic; Cell Line, Tumor; Biomarkers, Tumor; Disease Progression; Data Mining; Humans; Female

// Qin Luo 1, * , Yurong Zhang Ning Wang 1 Guangzhi Jin 2 Haojie Dishui Gu Xuemei Tao Xisong Huo Tianxiang Ge Wenming Cong Cun Wenxin State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School Medicine, Shanghai, China Department Pathology, Eastern Hepatobiliary Surgery Second Military Medical University, These authors contribute equally to this work Correspondence to: Qin, e-mail: [e-mail] Wang, [e-mail] Keywords: hepatocellular carcinoma, leukemia inhibitory factor receptor, high-grade dysplastic nodules, well differentiated-small carcinoma Received: December 10, 2014 Accepted: January 11, 2015 Published: February 05, ABSTRACT Differential diagnosis well-differentiated (WD-HCC) nodules (HGDNs) represents a challenge for pathologists. Several immunohistochemistry markers have been identified distinguish (HCC) from HGDNs. However, sensitivity or specificity the individual marker is still limited. In study, we analyzed dynamic alteration receptor (LIFR) CD34 during hepatocarcinogenesis small HCC. The diagnostic performance LIFR combination in WD-HCC HGDNs was investigated by logistic regression models validated an independent validation cohort. decreased increased along with stepwise progression low-grade (LGDNs) detection were 93.5% 90.5%, respectively. addition, colony formation assay used explore role tumorigenesis. Silencing could significantly promote HCC cells, whereas ectopic overexpression resulted impaired ability cells. findings indicate that may be as available differential model clinical practice.