miR-16 targets fibroblast growth factor 2 to inhibit NPC cell proliferation and invasion via PI3K/AKT and MAPK signaling pathways

• DOI: 10.18632/oncotarget.6504
• Publication Date: 2015-12-09T05:12:28Z
• Authors: Qingmei He; Xianyue Ren; Jiewei Chen; Yingqin Li; Xinran Tang; Xin Wen; Xiaojing Yang; Jian Zhang; Yaqin Wang; Jun Ma; Na Liu
• Keywords: 0301 basic medicine; Mice, Inbred BALB C; 0303 health sciences; Lung Neoplasms; Nasopharyngeal Carcinoma; Carcinogenesis; MAP Kinase Signaling System; Carcinoma; Mice, Nude; Nasopharyngeal Neoplasms; Genetic Therapy; 3. Good health; Gene Expression Regulation, Neoplastic; Mice; MicroRNAs; 03 medical and health sciences; Cell Line, Tumor; Disease Progression; Animals; Humans; Fibroblast Growth Factor 2; Neoplasm Invasiveness; Mitogen-Activated Protein Kinases; Research Paper; Cell Proliferation

// Qingmei He 1, * , Xianyue Ren Jiewei Chen Yingqin Li 1 Xinran Tang Xin Wen Xiaojing Yang Jian Zhang Yaqin Wang Jun Ma Na Liu Sun Yat-Sen University Cancer Center, State Key laboratory of Oncology in South China, Collaborative Innovation Center Medicine, Guangzhou, People’s Republic China These authors contributed equally to this work Correspondence to: Liu, e-mail: [e-mail] Keywords: miR-16, fibroblast growth factor 2, nasopharyngeal carcinoma, tumor growth, metastasis Received: August 13, 2015      Accepted: November 21, Published: December 08, 2015 ABSTRACT Dysregulation miRNAs has been shown contribute the carcinogenesis and progression carcinoma (NPC). Our previous microarray data showed that miR-16 expression is significantly decreased archived NPC tissues. Here, we confirmed was reduced cell lines freshly-frozen samples. Ectopic suppressed proliferation, migration, invasion vitro inhibited metastatic colonization lung vivo . Furthermore, 2 ( FGF2 ) identified as a direct target both phosphoinositide-3- kinase/AKT PI3K/AKT mitogen-activated protein kinase MAPK signaling pathways were repressed after overexpression. In addition, restoration reversed suppressive effects miR-16. Together, these results indicated suppresses by targeting thereby representing potential for miRNA-based therapy future.