Pre-neoplastic epigenetic disruption of transcriptional enhancers in chronic inflammation

• DOI: 10.18632/oncotarget.7513
• Publication Date: 2016-02-20T03:59:26Z
• Authors: Aline C. Planello; Rajat Singhania; Ken J. Kron; Swneke D. Bailey; David Roulois; Mathieu Lupien; Sérgio R. Peres Line; Ana Paula de Souza; Daniel D. De Carv...
• Keywords: Epigenome

// Aline C. Planello 1,2,* , Rajat Singhania 1,* Ken J. Kron 1 Swneke D. Bailey David Roulois Mathieu Lupien 1,3 Sérgio R. Peres Line 2 Ana Paula de Souza and Daniel De Carvalho Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada Department of Morphology, Piracicaba Dental School, Campinas, Piracicaba, SP, Brazil 3 Medical Biophysics, * These authors have contributed equally to this work Correspondence to: Carvalho, email: Souza, Keywords : DNA methylation, enhancers, chronic periodontitis, oral cavity squamous cell carcinoma Received December 14, 2015 Accepted February 09, 2016 Published 19, Abstract Chronic periodontitis (CP) is a inflammatory disease independently associated with higher incidence (OSCC). However, the molecular mechanism responsible for increased unknown. Here we profiled methylome CP patients healthy controls compared large set OSCC samples from TCGA. We observed significant overlap between altered methylation patterns in OSCC, suggesting an emergence pre-neoplastic epigenome CP. Remarkably, hypermethylated CpGs were significantly enriched enhancer elements. This aberrant functional able disrupt activity by preventing binding chromatin looping factors. study provides new insights on mechanisms linking inflammation tumor predisposition, highlighting role epigenetic disruption transcriptional enhancers.