Beneficial bacteria inhibit cachexia

• DOI: 10.18632/oncotarget.7730
• Publication Date: 2016-02-26T04:03:33Z
• Authors: Bernard J. Varian; Sravya Goureshetti; Theofilos Poutahidis; Jessica R. Lakritz; Tatiana Levkovich; Caitlin Kwok; Konstantinos Teli...; Yassin M. Ibrahim; Sheyla Mirabal; Susan E. Erdman
• Keywords: Lactobacillus reuteri

Muscle wasting, known as cachexia, is a debilitating condition associated with chronic inflammation such during cancer. Beneficial microbes have been shown to optimize systemic inflammatory tone good health; however, interactions between and host immunity in the context of cachexia are incompletely understood. Here we use mouse models test roles for bacteria muscle wasting syndromes. We find that feeding human commensal microbe, Lactobacillus reuteri, mice sufficient lower indices inhibit cachexia. Further, microbial muscle-building phenomenon extends normal aging wild type animals exhibited increased growth hormone levels up-regulation transcription factor Forkhead Box N1 [FoxN1] thymus gland retention longevity. Interestingly, defective FoxN1 gene (athymic nude) fail sarcopenia after L. reuteri therapy, indicating FoxN1-mediated mechanism. In conclusion, symbiotic may serve stimulate thymic functions regulate inflammation, offering possible alternatives prevention novel insights into microbiota mammalian ontogeny phylogeny.