cRGD inhibits vasculogenic mimicry formation by down-regulating uPA expression and reducing EMT in ovarian cancer

• DOI: 10.18632/oncotarget.8079
• Publication Date: 2016-03-15T06:35:51Z
• Authors: Jiao Tang; Jianguo Wang; Lin Fan; Xiaoxuan Li; Na Liu; Wanxian Luo; Jihui Wang; Yifeng Wang; Ying Wang
• Keywords: Vasculogenic mimicry

Vasculogenic minicry (VM), an alternative blood supply modality except to endothelial cells-mediated vascular network, is a potential therapeutic target for ovarian cancer due VM correlated with poor prognosis in patients. Accelerated extracellular matrix (ECM) degradation prerequisite formation induced by epithelial-mesenchymal transition (EMT). Previous reports demonstrate uPA has ability degrade ECM thereby promoting tumor angiogenesis. Also, exogenous cRGD sequence enables modulate expression, attenuate EMT and suppress endothelial-lined channels. Till now, the correlation of effect on remain unknown. Herein, we validate expression positively tissues (90 cases) cells (SKOV-3, OVCAR-3 A2780 cells). In particular, silencing experiments show that down-regulated causes notable decrease complete channels formed SKOV-3 cells. Mechanism study discloses promotes regulating AKT/mTOR/MMP-2/Laminin5γ2 signal pathway. The result demonstrates may serve as cancer. it found inhibit via not only down-regulating but also reducing EMT. Exogenous be promising angiogenic inhibitor therapy its inhibiting well network.