LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population

• DOI: 10.18632/oncotarget.8178
• Publication Date: 2016-03-18T11:30:14Z
• Authors: Jing He; Wei Zhong; Jixiao Zeng; Jinhong Zhu; Ruizhong Zhang; Fenghua Wang; Tianyou Yang; Yan Zou; Huimin Xia
• Keywords: Genome-wide Association Study

// Jing He 1, 2, * , Wei Zhong Jixiao Zeng Jinhong Zhu 3 Ruizhong Zhang 1 Fenghua Wang Tianyou Yang Yan Zou Huimin Xia Department of Pediatric Surgery, Guangzhou Institute Pediatrics, Women and Children's Medical Center, University, 510623, Guangdong, China 2 Sun Yat-Sen University Cancer State Key Laboratory Oncology in South China, Experimental Research, Collaborative Innovation Center for Medicine, 510060, Molecular Epidemiology Harbin Hospital, 150040, Heilongjiang, These authors contributed equally to this work Correspondence to: Xia, e-mail: [e-mail] Keywords: neuroblastoma, LMO1, polymorphism, genetic susceptibility Received: November 30, 2015 Accepted: February 21, 2016 Published: March 18, ABSTRACT Neuroblastoma is one the most commonly diagnosed extracranial solid tumors infancy; however, etiology neuroblastoma remains largely unknown. Previous genome-wide association study (GWAS) indicated that several common variations (rs110419 A > G, rs4758051 G A, rs10840002 rs204938 G) LIM domain only (LMO1) gene were associated with susceptibility. The aim was evaluate correlation between four GWAS-identified LMO1 polymorphisms risk a Southern Chinese population. We genotyped 256 cases 531 controls. Odds ratios (ORs) 95% confidence intervals (CIs) used strength associations. False-positive report probability calculated all significant findings. found rs110419 polymorphism significantly decreased (AG vs. AA: adjusted OR = 0.65, CI 0.47–0.91; GG 0.58, 0.36–0.91; AG/GG 0.63, 0.46–0.86), protective effect more predominant children age 18 months, males, subgroups tumor adrenal gland mediastinum, patients clinical stages III/IV. results suggested may contribute protection against neuroblastoma. Our findings call further validation studies larger sample size.