HDAC5, a potential therapeutic target and prognostic biomarker, promotes proliferation, invasion and migration in human breast cancer

• DOI: 10.18632/oncotarget.9274
• Publication Date: 2016-05-10T19:11:33Z
• Authors: Anqi Li; Zebing Liu; Ming Li; Shuling Zhou; Yan Xu; Yaoxing Xiao; Wentao Yang
• Keywords: Histone deacetylase 5

Histone deacetylase 5 (HDAC5) is an important protein in neural and cardiac diseases a potential drug target. However, little known regarding the specific role of HDAC5 breast cancer (BC). We aimed to evaluate expression human tumors determine effects inhibition BC cells.HDAC5 was evaluated patients correlated with clinical features patient prognosis. Functional experiments were performed using shRNA selective HDAC inhibitor LMK-235 for knockdown cells. The synergistic proteasome bortezomib also examined.HDAC5 extensively expressed tissues, high associated inferior Knockdown inhibited cell proliferation, migration, invasion, enhanced apoptosis. growth induced apoptosis, while inclusion synergistically efficacy LMK-235.Our findings indicate that promising prognostic marker target combination presents novel therapeutic strategy BC.