NEURL rs6584555 and CAND2 rs4642101 contribute to postoperative atrial fibrillation: a prospective study among Chinese population

• DOI: 10.18632/oncotarget.9422
• Publication Date: 2016-05-22T06:04:43Z
• Authors: Tiemin Wei; Jingjing Song; Min Xu; Lingchun Lv; Chong Liu; Jiayi Shen; Ying Huang
• Keywords: Male; China; Genotype; Muscle Proteins; Polymorphism, Single Nucleotide; 03 medical and health sciences; Postoperative Complications; 0302 clinical medicine; Asian People; Gene Frequency; Atrial Fibrillation; Humans; Genetic Predisposition to Disease; Postoperative Period; Prospective Studies; Coronary Artery Bypass; Aged; Middle Aged; 3. Good health; Case-Control Studies; Regression Analysis; Female; Clinical Research Paper; Transcription Factors

// Tiemin Wei 1,* , Jingjing Song 2,* Min Xu Lingchun Lv Chong Liu 1 Jiayi Shen and Ying Huang 3 Vasculocardiology Department, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Zhejiang Central Lishui, Zhejiang, P.R. China 2 Department Radiology, Cardiology, Sichuan Sichuan, * These authors have contributed equally to this article Correspondence to: Wei, email: Keywords : susceptibility; atrial fibrillation; coronary artery bypass graft surgery; SNP Received December 10, 2015 Accepted April 16, 2016 Published May 17, Abstract Postoperative fibrillation (POAF) is a serious, common complication after grafting (CABG) surgery. Recently, 5 novel loci were identified be associated with susceptibility using combination genotyping, eQTL mapping, functional validation. In current study, we aim evaluated the positive findings for POAF CABG among Chinese population, population-based, two-stage, nested case-control study 1,400 patients. NEURL rs12415501 CAND2 rs4642101 significantly population in both stages. When pooled together, ORs each additional copy minor allele was 1.29 (95% CI: 1.13-1.48, P = 1.7×10 -4 ) rs12415501, 1.21 1.08-1.36, 9.8×10 rs4642101. Functional validation experiments found AF risk rs6584555 correlated an increased expression its corresponding genes ( <0.001). independently collected cardiac surgery cohort, replicated previous findings, are patients who undergo population.