Exploring Diallelic Genetic Markers: TheHardyWeinbergPackage

• DOI: 10.18637/jss.v064.i03
• Publication Date: 2015-09-21T20:30:55Z
• Authors: Jan Graffelman
• Keywords: 0301 basic medicine; Àrees temàtiques de la UPC::Matemàtiques i estadística; Statistics; :Matemàtiques i estadística [Àrees temàtiques de la UPC]; log-ratio; Q-Q plot; Estadística matemàtica -- Aplicacions; HA1-4737; power; Mathematical statistics; 03 medical and health sciences; exact test; chi-square test; ternary plot; permutation test; log-ratio.

Testing genetic markers for Hardy-Weinberg equilibrium is an important issue in genetic association studies. The HardyWeinberg package o ers the classical tests for equilibrium, functions for power computation and for the simulation of marker data under equilibrium and disequilibrium. Functions for testing equilibrium in the presence of missing data by using multiple imputation are provided. The package also supplies various graphical tools such as ternary plots with acceptance regions, log-ratio plots and Q-Q plots for exploring the equilibrium status of a large set of diallelic markers. Classical tests for equilibrium and graphical representations for diallelic marker data are reviewed. Several data sets illustrate the use of the package.