The adoptr Package: Adaptive Optimal Designs for Clinical Trials in R

• DOI: 10.18637/jss.v098.i09
• Publication Date: 2021-06-28T14:01:55Z
• Authors: Kevin Kunzmann; Maximilian Pilz; Carolin Herrmann; Geraldine Rauch; Meinhard Kieser
• Keywords: R package; Interim; Adaptive design; Software package

Even though adaptive two-stage designs with unblinded interim analyses are becoming increasingly popular in clinical trial designs, there is a lack of statistical software to make their application more straightforward. The package adoptr fills this gap for the common case one- or two-arm trials (approximately) normally distributed outcomes. In contrast previous approaches, optimizes entire design upfront which allows maximal efficiency. To facilitate experimentation different objective functions, supports flexible way specifying both (composite) scores and (conditional) constraints by user. Special emphasis was put on providing measures aid practitioners validation process package.