Histocompatible Healing of Periodontal Defects After Application of an Injectable Calcium Phosphate Bone Cement. A Preliminary Study in Dogs

• DOI: 10.1902/jop.2002.73.9.1043
• Publication Date: 2005-02-02T12:25:20Z
• Authors: Yoshinori Shirakata; Shigeru Oda; Atsuhiro Kinoshita; Shigenari Kikuchi; Hiroaki Tsuchioka; Isao Ishikawa
• Keywords: Periodontal fiber; Calcium phosphate cement; Mandible (arthropod mouthpart); Beagle

Background: A novel injectable, fast setting calcium phosphate cement (CPC) is currently used in orthopedic therapy for bone fractures. This study evaluated the possibility of applying this to healing periodontal defects. Methods: Fenestrations and 3‐walled defects were surgically created on bilateral first molars canines 5 beagle dogs. CPC was applied one side mandible. Untreated contralateral served as controls. all maxilla. Twelve weeks after surgery, animals sacrificed decalcified undecalcified specimens prepared. Periodontal tissue histologically histometrically under a light microscope. Results: Healing tissues terms cementum formation consistently observed CPCapplied sites. partly replaced by new bone. The residual appeared detached from denuded root surface. New ligament‐like between No unfavorable reaction noted CPC‐applied statistically significant difference experimental or control sites histometric analysis. Conclusions: Although there no differences 2 treatment groups, histological observation indicated that seemed act scaffold provided histocompatible study. might be applicable therapy; however, further investigations are required. J Periodontol 2002;73:1043‐1053.