Histocompatible Healing of Periodontal Defects After Application of an Injectable Calcium Phosphate Bone Cement. A Preliminary Study in Dogs
Calcium Phosphates
Dental Cementum
Male
Bone Regeneration
Bone Cements
Biocompatible Materials
Calcium Carbonate
Injections
Phosphates
03 medical and health sciences
Dogs
0302 clinical medicine
Alveolar Process
Animals
Regeneration
Periodontal Diseases
DOI:
10.1902/jop.2002.73.9.1043
Publication Date:
2005-02-02T12:25:20Z
AUTHORS (6)
ABSTRACT
Background: A novel injectable, fast setting calcium phosphate cement (CPC) is currently used in orthopedic therapy for bone fractures. This study evaluated the possibility of applying this cement to healing periodontal defects.Methods: Fenestrations and 3‐walled periodontal defects were surgically created on bilateral first molars and canines in 5 beagle dogs. CPC was applied to the defects on one side of the mandible. Untreated defects on the contralateral side served as controls. CPC was applied to all defects in the maxilla. Twelve weeks after surgery, the animals were sacrificed and decalcified and undecalcified specimens were prepared. Periodontal tissue healing was evaluated histologically and histometrically under a light microscope.Results: Healing of periodontal tissues in terms of bone and cementum formation was consistently observed in the CPCapplied sites. CPC was partly replaced by new bone. The residual CPC appeared detached from the denuded root surface. New cementum and periodontal ligament‐like tissue were observed between the detached CPC and root surface. No unfavorable reaction was noted in the CPC‐applied sites. No statistically significant difference was noted in the experimental or control sites under histometric analysis.Conclusions: Although there were no statistically significant differences between the 2 treatment groups, histological observation indicated that CPC seemed to act as a scaffold for bone formation and provided histocompatible healing of periodontal tissues in this study. This cement might be applicable to periodontal therapy; however, further investigations are required. J Periodontol 2002;73:1043‐1053.
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