Toxicological Evaluation of Oral Administration of <em>Phoenix dactylifera</em> L. Fruit Extract on the Histology of the Liver and Kidney of Wistar Rats

• DOI: 10.19026/ijava.6.5630
• Publication Date: 2019-04-18T13:15:03Z
• Authors: Abel Nosereme Agbon; Helen Ochuko Kwan...; Wilson Oliver Hamman; S.J. Sambo
• Keywords: Phoenix dactylifera; Histology; Phytochemical

Various parts of <em>Phoenix dactylifera</em> (date palm) are used in traditional medicine to treat various disorders such as fever, abdominal troubles, etc., different the world. A preliminary phytochemical screening aqueous fruit extract (AFPD) revealed presence alkaloids, tannins, saponins, flavonoids and carbohydrates. This study was designed investigate effects oral administration AFPD on histology liver kidney Wistar rats. Thirty-nine rats were divided into two groups-control (three rats) treatment (thirty-six rats). The animals experimental group further categorised for phase (eighteen three groups; six rats/group each phase). In first phase, groups (A, B C) administered (10, 100 1000 mg/kg, oral, respectively). second (D, E F) (1600, 2900 5000 both phases, after 24 h administration, sacrificed other 21 days. Histopathological examinations sections compared with control. No mortality or signs toxicity observed upon AFPD, even at doses high which confirmed by mild pathological changes remarkable recovery result demonstrates that LD<50</sub> is greater than mg/kg relatively safe.