Prevalence of Glucose 6 Phosphate Dehydrogenase deficiency in Eastern India, a Study from a Tertiary Care Hospital

• DOI: 10.19080/jojph.2017.02.555599
• Publication Date: 2021-11-26T11:28:22Z
• Authors: Mukherjee Sudeb
• Keywords: Glucose-6-Phosphate Dehydrogenase Deficiency; Tertiary care

a. Background: Glucose 6 phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive hereditary disease characterized by abnormally low levels of dehydrogenase.Certain racial and ethnic groups have increased incidence this deficiency.This study destined to reveal the prevalence G6PD in Eastern India population.b. Methods: Total 250 patients (186 male 64 female) were included study.They subsequently categorized into various subgroups analysed properly.c.Results: was found overall 10 % population part world.Prevalence higher tribal community compared non community. d. Conclusion:Given large proportion suffering from mass screening programme should be implemented prevent drugs (antimalarial others) induced unwarranted catastrophe. Materials Methods:The present on carried out individuals attending Inpatient section Department Medicine R G KAR Medical College Hospital, Kolkata.The glucose enzyme cases admitted Hospital for varying reasons done with help commercially available kit detecting erythrocyte enzymes.This based principle method originally devised Kornberg Horecker Lohr Waller modified recommendation ICSH.Besides routine investigation, following investigations also special attention all cases.i. Complete blood count.ii. Reticulocyte count.iii.Comment peripheral smear.iv.Quantitative estimation enzyme. Quantitative Estimation enzyme:a. Laboratory Procedures: This kit.It a sigma procedure modification spectrophotometric methods [1], [2].This involves measurement rate increase reduction NADP NADPH its absorbance at 340 nm serves quantify enzymatic activity.Observation & Results: Table 1 shows that total no. studied (n = 250), maximum observed 21-40 years age group (49.2%).The varies 14 60 years.Table 2 74.4 males while 25.6 females.The (49.2 %).Table 3 among 55% belonged Tribal 45 Non-tribal community.Among females 36 community.The selected sample frame 10%, details which been shown (Table 4).Comparison activity between showed 60% deficient belong rest 40 5).Further analysis regarding gender distribution different communities has andTable 7. Discussion: In Chatterjee et al. (1961) worked mixed Indian investigated reported 5% Konkan Hindus Parsis, Bengalis, 6% Muslims, 8% Nepalese 11% Uttar Pradesh Bihar including Jharkhand [3].Thirteen biochemically variants India.At