Inhibitory Effect of a Sesquiterpene fromArtemisia iwayomogion Expression of Inducible Nitric Oxide Synthase by Suppression of I-κBα Degradation in LPS-stimulated RAW 264.7 Cells

• DOI: 10.20307/nps.2017.23.2.92
• Publication Date: 2017-08-14T10:05:06Z
• Authors: Na Yeon Kim; Hye Jin Koh; Hua Li; Hwa Jin Lee; Jae-Ha Ryu
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences

A sesquiterpene was purified from Artemisia iwayomogi methanolic extract during the course of searching anti-inflammatory principle medicinal plants. identified as armefolin inhibited production nitric oxide (NO) and attenuated inducible synthase (iNOS) protein level in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Armefolin also down-regulated mRNA expressions iNOS pro-inflammatory cytokines, interleukin-1β interleukin-6 LPS-activated macrophages. Moreover, suppressed degradation inhibitory-κBα (I-κBα) These data suggest that A. can suppress LPS-induced NO expression gene through inhibiting I-κBα. Taken together, might be a candidate promising agent.