Severe Acute Hepatitis E in a Woman with an Autoimmune Background

• DOI: 10.20344/amp.10429
• Publication Date: 2020-06-01T09:36:26Z
• Authors: Maria S.J. Nascim...; Madalena Almeida-...; Maria Fernandes; Fernando Maltez; Sara Lino; Martin D. Curran; João R. Mesquita
• Keywords: Autoimmune Hepatitis; Hepatitis E Virus; Elevated transaminases

Hepatitis E virus genotype 3 infections are normally asymptomatic in immunocompetent individuals. Symptomatic cases of acute icteric hepatitis seldom observed among women, younger men and children but particularly seen middle-aged/elderly men. We report a case severe caused by an 40-year-old woman that required prolonged hospitalization. Her medical history included autoimmune background, namely atrophic gastritis Graves’ disease. She presented extensive hepatic necrosis as revealed the high levels aminotransferases (ALT 4893 U/L; AST 3138 U/L). showed also coagulation disorder (prothrombin time; INR = 1.33). Serological markers for viruses A, B C were negative serum was positive RNA. Sequencing phylogenetic analysis strain belonged to subgenotype 3a. This is suggestive association between infection background.