The impact of cytogenetic evolution and acquisition of del(17p) on the prognosis of multiple myeloma patients

• DOI: 10.20452/pamw.15316
• Publication Date: 2020-04-27T17:13:33Z
• Authors: Aleksander Salomo...; Aleksandra Bluszcz; Agnieszka Krzywdz...; Zofia Spyra-Górny; Natalia Jakacka; Joanna Barankiewicz; Katarzyna Borg; Iwona Solarska; Tomasz Szpila; Bartosz Puła; Sebastian Grosicki; Krzysztof Jamroziak
• Keywords: 0303 health sciences; 03 medical and health sciences; 3. Good health

ARTICLE Prognostic impact of cytogenetic evolution in multiple myeloma 483 transplant (auto -HSCT) 11 have significantly improved the prognosis patients with MM.However, most cases MM are still incurable.Recent studies using next -generation sequencing (NGS) approaches provided evidence that is characterized by spatial and temporal genetic heterogeneity composed populations genetically distinct subclones, which evolve over time following a pattern INTRODUCTION Multiple (MM) third common hematologic malignancy European Union, approximately 33 000 new 20 deaths annually. 1he introduction novel agents, such as proteasome inhibitors (PIs), 2-4 immunomodulatory drugs (IMiDs), 5 -7 anti -CD38 monoclonal antibodies 8 -10 along high -dose melphalan followed autologous hematopoietic stem cell