INHIBITORY ACTIVITY OF COBALT(II)–MORIN COMPLEX AGAINST THE REPLICATION OF DENGUE VIRUS TYPE 2

• DOI: 10.20473/ijtid.v6i6.6126
• Publication Date: 2017-12-22T05:31:19Z
• Authors: Teguh Hari Sucipto; Siti Churrotin; Harsasi Setyawati...; Kris Cahyo Mulyatno; Ilham Harlan Amar...; Shuhai Ueda; Tomohiro Kotaki; Sri Sumarsih; Puspa Wardhani; Sri Subekti Bendr...; Aryati Aryati; Soegeng Soegijanto; Masanori Kameoka
• Keywords: Aedes albopictus; Vero cell; IC50; Morin; Infectious dose

Dengue virus (DENV) is a significant pathogen emerging worldwide as cause of infectious disease. Antidengue treatments are urgently required to control the emergence dengue. DENV mosquito-borne disease responsible for acute systemic diseases and serious health conditions. DENVs were distributed in tropical sub-tropical areas transmitted humans by Aedes agypty albopictus. vaccine or antiviral has not yet been clinically approved humans, even though there have great efforts toward this end. Antiviral activity against an important alternative characterization development drugs. Metal–organic compounds reported exhibit fungicidal, bactericidal, activities its inhibitory was significant, at high concentration it more toxic replicating cells than stationary cell monolayers Vero cells. The aim study investigate effects Cobalt(II)–Morin complex. This compound further investigated effect on replication DENV-2 measured enzyme-linked immunosorbent assay value selectivity index (SI). SI determined ratio 50% cytotoxic (CC50) (IC50). IC50 complex 3.08 µg/ml, CC50 3.36 µg/ml; thus, 1.09. results demonstrate antidengue serotype 2 toxicity Further studies before Co(II)–Morin can be applied treatment infections.