Hydrogen sulfide: the gas that fuels longevity

• DOI: 10.20517/jca.2022.16
• Publication Date: 2022-04-15T03:10:02Z
• Authors: Erik A. Blackwood; Christopher C. Gl...
• Keywords: 0301 basic medicine; 03 medical and health sciences; Article; 3. Good health

The molecular determinants of lifespan can be examined in animal models with the long-term objective applying what is learned to development strategies enhance longevity humans. Here, we comment on a recent publication examining mechanisms that determine worms, Caenorhabditis elegans (C. elegans), where it was shown inhibiting protein synthesis increased levels transcription factor, ATF4. Gene expression analyses showed ATF4 genes responsible for formation gas, hydrogen sulfide (H2S). Further examination H2S C. by modifying proteins ways stabilize their structures and functions. has been improve cardiovascular performance mouse heart disease, clinical trials are underway test effects health These findings support concept nutrient deprivation, which slows leads ATF4-mediated production, may extend improving function system other systems influence